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西地那非 印度原装进口原料@黄 17373198032

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品牌: 西地那非
含量: 99%
形状: 白色粉状
包装: 铝箔袋
起订:
供货总量: 4000 kg
发货期限: 自买家付款之日起 1 天内发货
所在地: 湖南 长沙市
有效期至: 长期有效
最后更新: 2017-12-07 16:43
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【西地那非 印度原装进口原料@黄 17373198032】详细说明
 西地那非CAS:171599-83-0 
 
优质产品(/invest/)推荐,价格美意:西地那非|他达那非|伐地那非|西力士|甲磺酸西地那非|阿伐那非|氨基他达那非|乙基他达那非 现货供应(/sell/),当天发货,品质保证
 
西地那非USP 医药(/)级||枸橼酸西地那非  171599-83-0
中文名 :西地那非 
CAS:171599-83-0 ,   139755-83-2 
外文名 :Sildenafil 
化学名称:5-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-1-methyl-3-propyl-1,3a,6,7a-tetrahydro-pyrazolo[4,3-d]pyrimidin-7-one
译   名:昔多芬 
纯度(含量):99.8%以上
分子式 :C22H30N6O4S 
分子量 :474.58 
熔    点: 187~189℃ 
EINECS号: 252-082-4
本品是治疗阴茎勃起功能障碍(ED)的口服药。它是西地那非的枸橼酸盐,一种 对环磷酸鸟苷(cGMP)特异的5型磷酸二酯酶(PDE5)选择性抑制剂。 作用机制:阴茎勃起的生理机制涉及性刺激过程中阴茎海绵体内一氧化氮(NO) 的释放。NO激活鸟苷酸环化酶导致环磷酸鸟苷(cGMP)水平增高,使海绵体内平滑肌松弛,血液充盈。
⒈药效学 西地那非对阴茎勃起反应的作用:西地那非(Sildenafil,Viagra,万艾可)是高度选择性磷酸二酯酶5(PDE5)抑制剂,PDE5在阴茎海绵体中高度表达,而在其它组织中(包括血小板、血管和内脏平滑肌、骨骼肌),表达低下。西地那非通过选择性抑制PDE5,增强一氧化氮(NO)-cGMP途径,升高cGMP水平而导致阴茎海绵体平滑肌松弛,使勃起功能障碍患者对性刺激产生自然的勃起反应。勃起反应一般随西地那非剂量和血浆浓度的增加而增强。实验显示,药效可持续至4小时,但反应较2小时时弱。西地那非对心肌的反应:不论正常或病变的心脏传导组织、心肌细胞、内皮细胞、淋巴组织中均不存在PDE5,因而西地那非(PDE5抑制剂)无正性肌力作用,不能直接影响心肌收缩功能。
西地那非对心脏参数的影响:正常男性志愿者单剂口服西地那非100mg,未发生有临床意义的心电图改变。8位稳定性缺血性心脏病患者在Swan-Ganz导管监测下,分4次静脉注射了总量为40mg的西地那非,结果:静息状态下,患者的收缩和舒张压较基线时分别下降了7%和10%。静息右心房、肺动脉压、肺动脉楔压和心排出量分别 平均下降28%、28%、20%和7%。尽管此静脉注射剂量较健康(/article/7/)男性志愿者单剂口服西地那非100mg的平均峰值血药浓度高2~5倍,但患者运动时上述的血流动力学应答仍存在。
在性刺激时,阴茎海绵体非肾腺素能非胆碱能神经元以及血管内皮细胞一氧化氮合成(/article/8/)酶催化左旋精氨酸合成一氧化氮,后者激活鸟苷酸环化酶使环磷酸鸟苷合成增加,继而引起阴茎海绵体平滑肌和小动脉平滑肌的松弛,血液注入阴茎海绵窦,使阴茎勃起。同时环磷酸鸟苷又受磷酸二酯酶的水解。
主要成分及化学名称:1-[4-乙氧基-3-[5-(6,7-二氢-1-甲基-7-氧代-3-丙基-1H-吡唑并[4,3d]嘧啶)]苯磺酰]-4-甲基哌嗪枸橼酸盐 本品为蓝色菱形薄膜衣,除去薄膜衣后为白色粉剂。
作    用:勃起功能障碍
枸橼酸西地那非”台湾叫威而钢,台湾威而钢处方药,适应症范围只限于患有男性原是由美国辉瑞(Pfizer)制药(/)公司(/company/)研制生产的一种治疗心绞痛的药物(/)。在临床试验(/sell/24/)中发现其治疗心绞痛的效果一般,而对治疗阳痿却有特殊效果,这一意外发现,促使厂家(/company/)干脆以治疗阳痿的药物申报。美国食品和药品(/)管理局(FDA(/article/11/))于1997年3月27日正式批准该药作为治疗阳痿的专用药物。
西地那非对视觉的影响:研究表明,服用2倍于最大推荐剂量的药物时,本品对视力、视网膜电流图、眼压和视乳头大小无影响。可有一过性蓝绿颜色辨别异常。 无论单独使用或与阿司匹林合用,本品对人出血时间没有影响。体外实验中,本品增强硝普钠(NO供体)的抗人类血小板凝聚作用。 健康志愿者单剂口服西地那非100mg后,精子的活动力和形态未受影响。
不良反应:头痛、潮红、消化不良、鼻塞及视觉异常等。视觉异常为轻度和一过性的,主要表现为视物色淡、光感增强或视物模糊。
用法用量:用作片剂、胶囊、热饮等,用量为130-180毫克,起效时间:15分钟,持续时间:3天。
优点:枸橼酸西地那非优点在于服用量少、副作用非常小、且溶于热水和乙醇。
优质产品推荐:西地那非|他达那非|伐地那非|西力士|甲磺酸西地那非|阿伐那非|氨基他达那非|乙基他达那非 现货供应,当天发货,品质保证
 
 
 
 
 
 
 
 
Sildenafil CAS: 171599-83-0
 
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Sildenafil USP Pharmaceutical grade || Sildenafil citrate 171599-83-0
Chinese name: sildenafil
CAS: 171599-83-0, 139755-83-2
English name: Sildenafil
Chemical Name: 5- [2-Ethoxy-5- (4-methyl-piperazine-1-sulfonyl) -phenyl] -1-methyl-3-propyl-1,3a, 6,7a-tetrahydro-pyrazolo [4,3 -d] pyrimidin-7-one
Translated by:
Purity (content): 99.8% or more
Molecular formula: C22H30N6O4S
Molecular weight: 474.58
Melting point: 187 ~ 189 ℃
EINECS number: 252-082-4
This product is the treatment of penile erectile dysfunction (ED) oral medication. It is citrate of sildenafil, a selective inhibitor of type 5 phosphodiesterase (PDE5) specific for cyclic guanosine monophosphate (cGMP). Mechanisms: The physiological mechanism of penile erection involves the release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO activating guanylate cyclase results in elevated levels of cyclic guanosine monophosphate (cGMP), smooth muscle relaxation in the corpus cavernosum, and blood filling.
(Sildenafil, Viagra, Viagra) is a highly selective phosphodiesterase 5 (PDE5) inhibitor, PDE5 is highly expressed in the corpus cavernosum, and the effect of sildenafil on penile erection is: While in other tissues (including platelets, blood vessels and visceral smooth muscle, skeletal muscle), expression is low. Sildenafil causes selective erectile response to sexual stimulation by selective inhibition of PDE5, enhancement of nitric oxide (NO) -cGMP pathway, increased cGMP levels resulting in smooth muscle relaxation of the penile corpus cavernosum. Erectile response is generally enhanced with the increase in sildenafil and plasma concentrations. Experiments show that the efficacy of sustainable to 4 hours, but the reaction is less than 2 hours. Sildenafil response to myocardium: PDE5 is absent in normal or diseased cardiac conduction tissue, cardiomyocytes, endothelial cells, lymphoid tissue, so that sildenafil (PDE5 inhibitor) has no positive muscle strength, Directly affect the myocardial systolic function.
Effects of sildenafil on cardiac parameters: Normal male volunteers were orally administered 100 mg of sildenafil, with no clinically significant electrocardiogram changes. 8 patients with stable ischemic heart disease under the monitoring of Swan-Ganz catheter, 4 times intravenous injection of a total of 40mg of sildenafil, the results: resting state, the patient's contractility and diastolic blood pressure than baseline Respectively, down 7% and 10%. Resting right atrium, pulmonary artery pressure, pulmonary artery wedge pressure and cardiac output were down by 28%, 28%, 20% and 7%, respectively. Although this intravenous dose was 2 to 5 times higher than the mean peak plasma dose of sildenafil 100 mg for healthy male volunteers, the above hemodynamic response was still present.
In the sexual stimulation, the corpus cavernosum non-gonadotropin can non-cholinergic neurons and vascular endothelial cells nitric oxide synthase catalyzes L-arginine synthesis of nitric oxide, which activates guanylate cyclase to ring Guanosine synthesis increased, and then cause penile corpus cavernosum smooth muscle and small artery smooth muscle relaxation, blood into the penis cavernous sinus, so that penile erection. At the same time, cyclic guanosine monophosphate is hydrolyzed by phosphodiesterase.
Main Ingredients and Chemical Name: 1- [4-Ethoxy-3- [5- (6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo [4 , 3d] pyrimidine)] benzenesulfonyl] -4-methylpiperazine citrate This product is a blue rhombic film, remove the film after the white powder.
Role: erectile dysfunction
Citrate sildenafil "Taiwan called Wei and steel, Taiwan Granville and steel prescription drugs, the scope of indications is limited to suffering from men was originally developed by the United States Pfizer (Pfizer) pharmaceutical companies to produce a treatment of angina drugs in clinical The trial found that the effect of treatment of angina in general, and the treatment of impotence has a special effect, the accident found that manufacturers to promote the treatment of impotence drugs to declare the US Food and Drug Administration (FDA) on March 27, 1997 Formally approved the drug as a special treatment for impotence drugs.
Effects of sildenafil on the visual: The study showed that taking 2 times the maximum recommended dose of the drug, the goods on the vision, retinal current, intraocular pressure and optic disc size had no effect. Can have a transient blue-green color to identify abnormalities. Whether used alone or in combination with aspirin, this product has no effect on human bleeding time. In vitro experiments, this product enhanced sodium nitroprusside (NO donor) anti-human platelet aggregation. The activity and shape of the spermatozoa were not affected after a single dose of oral administration of sildenafil 100 mg.
Adverse reactions: headache, flushing, indigestion, nasal obstruction and visual abnormalities. Visual abnormalities are mild and transient, mainly as a result of light color, light perception or blurred vision.
Dosage: used as tablets, capsules, hot drinks, etc., the amount of 130-180 mg, the onset time: 15 minutes, duration: 3 days.
Advantages: sildenafil citrate has the advantage of taking less, side effects are very small, and soluble in hot water and ethanol.
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